Scientists have developed hundreds of micro human brain

Brain human brain scientists human skin pluripotent stem cells

xinlangkeji· 2016-10-10 13:04:01

Align= >研究人员在实验室中培植出了数百个微型人类大脑,试图利用它们来研究自闭症和精神分裂症等精神障碍。而他们培植这些大脑的方法可以说简单得令人惊讶。这些“类器官”直径只有三至四毫米,结构类似于尚未发育成熟的人类大脑。图为迷你大脑放大后的照片。 "center"

研究人员利用人类皮肤细胞培育出了一些豌豆大小的“大脑”。图为发育中的人类大脑(左图)和“类大脑”(右图)的对比。

researchers have used human skin cells to produce some pea sized "brain". For the development of the human brain (left) and the "brain" (right) contrast.

研究人员利用人类皮肤细胞培育出了一些豌豆大小的“大脑”。图为发育中的人类大脑(左图)和“类大脑”(右图)的对比。

researchers have used human skin cells to produce some pea sized "brain". For the development of the human brain (left) and the "brain" (right) contrast.

why we are right-handed or southpaws? Why do we have autism? The human brain still has many mysteries. Researchers have developed hundreds of tiny human brains in the laboratory, trying to use them to study mental disorders such as autism and schizophrenia.

sina science and technology news Beijing time October 8th news, according to foreign media reports, why we are right-handed or left-handed? Why do we have autism? The human brain still has many mysteries. Some problems can be solved by studying the brains of other animals, such as rats and mice. But there are some unique problems that only the human mind will encounter.

recently developed hundreds of tiny human brains in the laboratory, trying to use them to study mental disorders such as autism and schizophrenia. The way they grow the brain can be surprisingly simple. These mini brains are produced by cells, the research team uses skin cells, but in fact, all types of cells can be.

Madeleine Lancaster (Lancaster Madeline) is a member of the Cambridge Medical Research Council of molecular medicine laboratory, she is one of the scientists involved in the study. "The brain's way of growth is exactly the same as in the embryo." Lancaster said the doctor.

scientists first use protein, these cells into stem cells, as they continue to grow, the brain cells will gradually be differentiated. Next, the researchers will interrupt the nutrients available to the cells, and for some unknown reason, the brain cells appear to be the most dynamic in these cells, and thus survive. The researchers then put these brain cells in a special gel, and then into the incubator for training.

"we are now primarily concerned with other neurological disorders, such as autism and mental retardation. We introduce the variation of the variants found in these diseases into the mini brain, and then study their pathogenesis on the basis of the development of the "class organ"." Dr. Lancaster said.

first in the bottle of the brain by the stem cell scientist in 2013 for the first time to cultivate success. The scientists hope that their findings will help us to find ways to treat neurological and psychiatric disorders. The "organ" is only three to four mm in diameter, a structure similar to the mature human brain, just like a normal brain, the "brain" is also divided into gray and white matter, but also contains specific regions of the brain.

Vienna Institute of molecular biotechnology Juergen Nobridge (Juergen Knoblich) from a head deformity in patients with connective tissue isolated from some induced pluripotent stem cells (iPS cells). Microcephaly is a rare, but extremely serious disease gene disorder patients, brain volume is much smaller than ordinary people, therefore suffering from a serious mental disorder. Like many neurological diseases, the disease is difficult to study in rats, because their brains are far less complex than ours. The research team of

using a 3D matrix scaffold, imitating human embryos in vivo environment, using a special experimental equipment named rotating bioreactor, provide nutrients and oxygen required for the brain. "This method gradually let us understand some of the defects in the development of the brain. We hope to eventually be able to use them to study some of the more common diseases, such as schizophrenia or autism, etc.." Professor Bridge said. "We hope to be able to model some of these defects."

scientists at the beginning of the goal is to develop a model that can be used to study the brain work mechanism, better understanding of brain diseases, as well as new drugs to test biological tools. Many researchers hope to develop a brain that is exactly the same as the human brain. But there are also a number of researchers believe that this goal is still difficult to achieve.

(Martin Coath Dr) of the University of Plymouth Institute of cognition questioned, how can someone try to develop a "real" human brain? The human brain, which has a normal function, has its own consciousness, has its own desires and dreams, can feel pain, and asks what we have done to it." He pointed out. "If we can develop a much simpler than the human brain's brain in the laboratory, it even on electronic eyes, electronic ears and hands, teach it to do something that has a lot of life and simple brain complex. But in my opinion, this is not so far away." (leaf)

Figure 1: researchers have developed hundreds of tiny human brains in the laboratory, trying to use them to study mental disorders such as autism and schizophrenia. The way they grow the brain can be surprisingly simple. These "organs" are only three to four mm in diameter and are similar to the human brain that is not yet mature. The picture is a photo of the mini brain enlargement.

Figure 2: the researchers used human skin cells to produce some pea sized "brain". For the development of the human brain (left) and the "brain" (right) contrast.

Figure 3: scientists using stem cells, skin cells into a three-dimensional organization of the human brain.

Figure 4: Why are we right-handed or left-handed? Why do we have autism? The human brain still has many mysteries. Researchers have developed hundreds of tiny human brains in the laboratory, trying to use them to study mental disorders such as autism and schizophrenia.

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